Make your weakness a solvable problem
There is considerable debate over whether you should focus your energy on mitigating weaknesses or improving your strengths. Let's look at one example. You're an amazing designer who is horrible at writing and sales.
On one hand, you can mitigate your issues: take a class on writing effective emails and attend a sales training. Now, you are okay at writing & selling. Your ability to attract clients has probably doubled! This is a big win.
On the other hand, you can make your weakness a solvable problem. You can hire someone to do your sales and translate your words into effective communication. Your ability to attract clients has probably 10x'ed. This is a crazy huge win.
A third option (I am out of hands!), you could work for a agency where selling isn't part of your job and communication is largely handled by someone else. Another win!
Moral of the story: mitigating key weaknesses can lead to big wins, but the exponential wins come from framing your weakness as a solvable problem -- and then taking the steps to take it off your plate.